Children living in upstream oil and natural gas (O&G) areas may be exposed to leukemogens and at increased risk for acute lymphoblastic leukemia (ALL). We conducted a case–control study of children born in Colorado between 1992 and 2019. We matched 451 children diagnosed with ALL at ages 2 to 9 years starting in 2002 to 2,706 controls based on birth month/year and Hispanic ethnicity. We estimated upstream O&G activity intensities from conception through a 10-year latency using our intensity-adjusted inverse distance weighted (IA-IDW) model. We applied logistic regression models adjusted for confounders to evaluate associations between ALL and IA-IDW.
Lisa M. McKenzieWilliam B. AllshouseDavid R. JohnsonChristopher C. DeVoeMyles CockburnDebashis Ghosh; Exposures from Oil and Gas Development and Childhood Leukemia Risk in Colorado: A Population-Based Case–Control Study. Cancer Epidemiol Biomarkers Prev 2025; https://doi.org/10.1158/1055-9965.EPI-24-1583